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National Measurement Institute
      

Bioanalysis Research

DNA helixThe Bioanalysis Group develops infrastructure to improve accuracy and comparability in biological measurement (e.g. DNA methylation and quantification using digital PCR) and undertakes collaborative projects, contract research and commercial analysis. Click here for an overview of our achievements and the new capabilities we have developed using the Australian Government’s NETS funding and here for details of our current projects.

For more information or to discuss your requirements contact +61 2 8467 3700 or biotesting@measurement.gov.au.

Customised DNA Reference Material

We develop measurement infrastructure and standards for nucleic acid and genomic measurements. We have extensive expertise in development of validated methods for characterising DNA using a range of complementary techniques, including quantitative real-time and digital PCR, mass spectrometry, high pressure liquid chromatography, capillary electrophoresis, Sanger sequencing and massive parallel sequencing. This expertise is utilised in design, preparation and characterisation of DNA reference materials for specific applications. Our DNA reference materials can be provided in solution or pre-dispensed in client-defined quantities into wells of a PCR plate.

Commercial Analysis

We provide a range of analytical services and contract research in nucleic acid measurement, including:

  • method development and validation
  • DNA reference material production and characterisation, including standards with a defined percent methylation or a defined number of copies of a single nucleotide polymorphism
  • stockfeed testing to identify the presence of contaminating meat and bone meal
  • genetically modified food testing in compliance with the requirements of ISO/IEC 17025, including NATA-accredited methods
  • genotyping analysis using digital PCR

Training

We conduct a training course in Estimating Measurement Uncertainty for Biologists which is also suitable for quantitative microbiology.

International Liaison

We have actively represented Australia on the Bioanalysis Working Group of the CCQM (Consultative Committee for Amount of Substance — Metrology in Chemistry) of the International Committee for Weights and Measures since its inception. Over the last 13 years, the goal of this working group has been to enable comparable and traceable biological measurements through appropriate measurement infrastructure. This relatively new field of science is referred to as biometrology and has applications in fields as diverse as agricultural biotechnology, diagnostics, forensic science, pharmaceutics and speciation. See also NMI 42 International Cooperation in Metrology – Research in Metrology for Chemistry and Biology. 

Technical Support to Government Agencies

We provide technical support to Government agencies and have produced the following reports: